PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAFV600E PIK3CA(H1047R) double mutant thyroid tumors

Matthias A Roelli; Dorothee Ruffieux-Daidie; Amandine Stooss; Oussama ElMokh; Wayne A Phillips; Matthias S Dettmer; Roch-Philippe Charles

Journal article

PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAFV600E PIK3CA(H1047R) double mutant thyroid tumors

Matthias A Roelli, Dorothee Ruffieux-Daidie, Amandine Stooss, Oussama ElMokh, Wayne A Phillips, Matthias S Dettmer, Roch-Philippe Charles

Oncotarget | IMPACT JOURNALS LLC | Published : 2017

DOI: 10.18632/oncotarget.21732

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University of Melbourne Researchers

Wayne Phillips Author The Sir Peter MacCallum Department of Oncology

Related Projects (1)

MOLECULAR AND THERAPEUTIC INTERACTIONS IN COLORECTAL CANCER

This project will use our unique preclinical models to unravel the molecular and cellular events underlying the cooperation between two impo..

Grants

Awarded by Swiss National Science Foundation

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This work was supported by the Swiss National Science Foundation grant 31003A_149824/1. The RPC lab is also supported by the Swiss National Science Foundation grant NCCR-TransCure. WAP is supported, in part, by project grant APP1080491 from the National Health and Medical Research Council (NHMRC) of Australia.