Journal article

Genetic basis of variation in adenoma multiplicity in Apc(Min/ ) Mom1(S) mice

J Haines, V Johnson, K Pack, N Suraweera, P Slijepcevic, E Cabuy, M Coster, M Ilyas, J Wilding, O Sieber, W Bodmer, I Tomlinson, A Silver

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2005

Abstract

Apc(Min) mice have provided an example of a locus (Modifier of Min1; Mom1) modifying adenoma numbers in the intestines of inbred strains. Linkage analysis located Mom1 on chromosome 4, and further investigation identified secretory phospholipase A2 (Pla2g2a) as a candidate gene. Because of unknown variation introduced by a single founding male mouse, our Min stock, although Pla2g2a(Mom1-s), was not on a pure C57BL/6J background and exhibited several polymorphic loci, including a region on chromosome 18 distal to Apc. Through selective breeding for homozygosity for distal chromosome 18 markers, six recombinant lines that presented with limited intraline variation in adenoma numbers were estab..

View full abstract

University of Melbourne Researchers