Journal article

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP

Nirosha Suraweera, Andrew Latchford, Amy McCart, Pauline Rogers, Sarah Spain, Oliver Sieber, Robin Phillips, Ian Tomlinson, Andrew Silver

JOURNAL OF MEDICAL GENETICS | B M J PUBLISHING GROUP | Published : 2007

Abstract

BACKGROUND: Reproductive factors have been shown by epidemiology studies to alter colorectal cancer risk in women. Familial adenomatous polyposis (FAP) patients carry a germline adenomatous polyposis coli (APC) mutation predisposing to multiple adenoma formation in the intestine. The Min mouse provides a good model of FAP, and we recently reported a significant increase in intestinal tumour multiplicity in a recombinant line of mice following pregnancy. AIM: We considered whether reproduction modulates intestinal tract disease in a large cohort of female patients with FAP (n = 180). RESULTS: Multiple regression analysis showed that the number of colonic polyps observed was not related to the..

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University of Melbourne Researchers