Journal article

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice

N Suraweera, J Haines, A McCart, P Rogers, A Latchford, M Coster, G Polanco-Echeverry, T Guenther, J Wang, O Sieber, I Tomlinson, A Silver

HUMAN MOLECULAR GENETICS | OXFORD UNIV PRESS | Published : 2006

Abstract

Min mice provide a good model of human familial adenomatous polyposis. Recently, we have reported on two recombinant inbred lines (I and V) and the location of a modifier (Mom3) close to Apc, which altered polyp numbers in our mice possibly by modifying the frequency of wild-type (WT) allele loss at Apc; mice with severe disease (line V) showed elevated rates of loss. We now show that in line I only, a single pregnancy caused a significant increase in adenoma multiplicity compared with virgin controls (P<0.001) and that an additional pregnancy conferred a similar risk. Pregnancy was linked to both adenoma initiation and enhanced tumour growth in line I mice, and interline crosses indicated t..

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University of Melbourne Researchers