Journal article
Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
S Bradburn, J McPhee, L Bagley, M Carroll, M Slevin, N Al-Shanti, Y Barnouin, JY Hogrel, M Pääsuke, H Gapeyeva, A Maier, S Sipilä, M Narici, A Robinson, D Mann, A Payton, N Pendleton, G Butler-Browne, C Murgatroyd
Neurobiology of Aging | ELSEVIER SCIENCE INC | Published : 2018
Abstract
Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorphism (rs56061981) that alt..
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Awarded by European Commission
Funding Acknowledgements
The authors would like to thank Professor David Proud (Department of Physiology and Pharmacology, University of Calgary, Canada) for kindly supplying the pGL4-CXCL10 plasmid. They would also like to thank all the participants and staff involved in the MyoAge and The University of Manchester Age and Cognitive Performance Research Cohort studies. The MyoAge study was supported by a research grant from the European Union FP7 (223576). Aspects of the experiments were also supported by a seedcorn grant (2015) from the Manchester Interdisciplinary Collaboration for Research on Ageing (MICRA).