Thesis / Dissertation

Dopamine receptors 1 and 2 in extinction of conditioned fear

A Guerin, JH Kim (ed.), HB Madsen (ed.)

Published : 2015

Abstract

Post-traumatic stress disorders, the most common type of anxiety disorder, affect more than 800,000 Australians it at any given time. It is currently treated using exposure therapy. In the laboratory, it is commonly modelled by Pavlovian fear conditioning and extinction. It is known that the dopaminergic system plays a major role in fear learning and extinction processes, and therefore presents a potential target for treatment of anxiety disorders. Dopamine activity in the brain is modulated by two main receptors: dopamine receptor 1 and 2 (D1R and D2R, respectively). They are distributed in different regions of the brain, including the medial prefrontal cortex (mPFC) and the basolateral amy..

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University of Melbourne Researchers