Journal article
Lamin A expression in circulating osteoprogenitors as a potential biomarker for frailty: The Nepean Osteoporosis and Frailty (NOF) Study
A Al Saedi, P Gunawardene, S Bermeo, S Vogrin, D Boersma, S Phu, L Singh, P Suriyaarachchi, G Duque
Experimental Gerontology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018
Abstract
Lamin A is a protein of the nuclear lamina. Low levels of lamin A expression are associated with osteosarcopenia in mice. In this study, we hypothesized that low lamin A expression is also associated with frailty in humans. We aimed to develop a non-invasive method to quantify lamin A expression in epithelial and circulating osteoprogenitor (COP) cells, and to determine the relationship between lamin A expression and frailty in older individuals. COP cells and buccal swabs were obtained from 66 subjects (median age 74; 60% female; 26 non-frail, 23 pre-frail, and 17 frail) participating at the Nepean Osteoporosis and Frailty (NOF) Study. We quantified physical performance and disability, and ..
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Funding Acknowledgements
[ "This work was supported by the Australian Association of Geriatrics and Gerontology (to PG), the Nepean Medical Research Foundation (to GD and PS), and the Australian Institute for Musculoskeletal Science (AIMSS) (to GD, AAS and LS).", "The authors would like to thank the Nepean Blue Mountains Local Health District for their support to the NOF Study." ]