Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro
Hannah EJ Yong, Padma Murthi, Bill Kalionis, Rosemary J Keogh, Shaun P Brennecke
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | ELSEVIER SCI LTD | Published : 2018
Decidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration and invasion; all effects that were attenuated by decidual ACVR2A siRNA transfection. These findings suggest that altered decidual ACVR2A expression perturbs the maternal-fetal crosstalk involved in regulating trophoblast function at the interface, wh..View full abstract
This study was funded by the Royal Women's Hospital, Melbourne, Australia. H.E.J. Yong was supported by the Melbourne International Fee Remission Scholarship and the Felix Meyer Scholarship in Obstetrics and Gynaecology from the University of Melbourne, Melbourne, Australia.