Journal article

Using minimalist self-assembling peptides as hierarchical scaffolds to stabilise growth factors and promote stem cell integration in the injured brain

AL Rodriguez, KF Bruggeman, Y Wang, TY Wang, RJ Williams, CL Parish, DR Nisbet

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | WILEY | Published : 2018

Abstract

Neurotrophic growth factors are effective in slowing progressive degeneration and/or promoting neural repair through the support of residual host and/or transplanted neurons. However, limitations including short half-life and enzyme susceptibility of growth factors highlight the need for alternative strategies to prolong localised delivery at a site of injury. Here, we establish the utility of minimalist N-fluorenylmethyloxycarbonyl (Fmoc) self-assembling peptides (SAPs) as growth factor delivery vehicle, targeted at supporting neural transplants in an animal model of Parkinson's disease. The neural tissue-specific SAP, Fmoc-DIKVAV, demonstrated sustained release of glial cell line derived n..

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Grants

Awarded by National Health and Medical Research Council


Awarded by NHMRC Dementia Research Leadership Fellowship


Awarded by Australian Research Council


Funding Acknowledgements

National Health and Medical Research Council, Grant/Award Number: GNT1135657; Victorian Government's Operational Infrastructure Support Grant; NHMRC Dementia Research Leadership Fellowship, Grant/Award Number: GNT1135657; Senior Medical Research Fellowship; Alfred Deakin Research Fellowship; Australian Research Council, Grant/Award Number: DP130103131; Australian Microscopy and Microanalysis Research Facility (AMMRF)