CD52 inhibits Toll-like receptor activation of NF-kappa B and triggers apoptosis to suppress inflammation
Maryam Rashidi, Esther Bandala-Sanchez, Kate E Lawlor, Yuxia Zhang, Alana M Neale, Swarna L Vijayaraj, Robert O'Donoghue, John M Wentworth, Timothy E Adams, James E Vince, Leonard C Harrison
Cell Death & Differentiation | NATURE PUBLISHING GROUP | Published : 2018
Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Government IRISS
We thank G. Naselli, K. Ngui, J. Bosco, N. Stone, R. Boehmer, N. Khan, L. Dagley, P. Nguyen for technical assistance and advice. We thank I. Wicks, J. Murphy, H. Thomas, S.L. Masters, A. Webb, R. Feltham, E. Petrie, S. Nicholson for insightful discussions. We thank L. Schofield for providing THP-1 cells, N. Lalaoui, D. Vaux and J. Silke for the ERK inhibitors and PARP antibody, NF-kappa B reporter, GEV-16 and MCL-1 cDNA constructs. G. Salvesen and M. Navarro for the inducible cFLIPL cDNA construct, P. Meier for the IKK-EE mutant construct and D. Huang, K. Mason and D. Gray for BAX/BAK double knockout mice, O. Takeuchi for the Bax<SUP>fl/fl</SUP> Bak<SUP>-/-</SUP> strain and J. Gilbert, M. Dayton, D. Cooper for technical assistance. This work was supported by the National Health and Medical Research Council of Australia Program Grant (LCH 1037321), Project Grants (LCH 1051484; JEV 1051210 and 1101405), Fellowships (LCH 1080887; JEV 1052598), and by operational infrastructure grants through the Australian Government IRISS (9000220) and the Victorian State Government OIS.