Journal article
Differences in regional grey matter volumes in currently ill patients with anorexia nervosa
A Phillipou, SL Rossell, C Gurvich, DJ Castle, LA Abel, RG Nibbs, ME Hughes
European Journal of Neuroscience | WILEY | Published : 2018
DOI: 10.1111/ejn.13793
Abstract
Neurobiological findings in anorexia nervosa (AN) are inconsistent, including differences in regional grey matter volumes. Methodological limitations often contribute to the inconsistencies reported. The aim of this study was to improve on these methodologies by utilising voxel-based morphometry (VBM) analysis with the use of diffeomorphic anatomic registration through an exponentiated lie algebra algorithm (DARTEL), in a relatively large group of individuals with AN. Twenty-six individuals with AN and 27 healthy controls underwent a T1-weighted magnetic resonance imaging (MRI) scan. AN participants were found to have reduced grey matter volumes in a number of areas including regions of the ..
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Awarded by Jack Brockhoff Foundation
Funding Acknowledgements
This research was supported by the Jack Brockhoff Foundation (L.A., S.R., D.C., A.P., grant number: 3410); the Dick and Pip Smith Foundation (A.P., L.A., S.R., D.C.); an Australian Postgraduate Award (A.P.); and the David Hay Memorial Fund Award (A.P.). The authors would like to thank Charlotte Keating for assisting with the clinical interview. The authors would also like to thank Chia Huang, Richard Newton, Lynley Gervasoni, Michelle Snell, Helen Shepherd, Philippa Harrison and Felicity Lawrence for their assistance in recruiting participants. Finally, the authors would like to thank everyone who took the time to participate in the study.