Haemodynamic effects of umbilical cord milking in premature sheep during the neonatal transition

DA Blank; GR Polglase; M Kluckow; AW Gill; KJ Crossley; A Moxham; K Rodgers; V Zahra; I Inocencio; F Stenning; DA Larosa; PG Davis; SB Hooper

Journal article

Haemodynamic effects of umbilical cord milking in premature sheep during the neonatal transition

DA Blank, GR Polglase, M Kluckow, AW Gill, KJ Crossley, A Moxham, K Rodgers, V Zahra, I Inocencio, F Stenning, DA Larosa, PG Davis, SB Hooper

Archives of Disease in Childhood Fetal and Neonatal Edition | BMJ PUBLISHING GROUP | Published : 2018

DOI: 10.1136/archdischild-2017-314005

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Abstract

Objective Umbilical cord milking (UCM) at birth may benefit preterm infants, but the physiological effects of UCM are unknown. We compared the physiological effects of two UCM strategies with immediate umbilical cord clamping (UCC) and physiological-based cord clamping (PBCC) in preterm lambs. Methods At 126 days' gestational age, fetal lambs were exteriorised, intubated and instrumented to measure umbilical, pulmonary and cerebral blood flows and arterial pressures. Lambs received either (1) UCM without placental refill (UCMwoPR); (2) UCM with placental refill (UCMwPR); (3) PBCC, whereby ventilation commenced prior to UCC; or (4) immediate UCC. UCM involved eight milks along a 10 cm length ..

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University of Melbourne Researchers

Peter Davis Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

PGD (app ID#1059111) is supported by an Australian National Health and Medical Research Council Practitioner and Principal Research Fellowship. PGD and SBH are supported by the Australian National Health and Medical Research Council Program (#606789). DB receives a scholarship for his PhD from Monash University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.