Journal article

Angiopoietin-1 is required for Schlemm's canal development in mice and humans

Benjamin R Thomson, Tomokazu Souma, Stuart W Tompson, Tuncer Onay, Krishnakumar Kizhatil, Owen M Siggs, Liang Feng, Kristina N Whisenhunt, Tammy L Yanovitch, Luba Kalaydjieva, Dimitar N Azmanov, Simone Finzi, Christine E Tanna, Alex W Hewitt, David A Mackey, Yasmin S Bradfield, Emmanuelle Souzeau, Shari Javadiyan, Janey L Wiggs, Francesca Pasutto Show all



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Awarded by NEI

Awarded by NCI CCSG

Awarded by Cancer Center Support Grant

Awarded by Vision Core Grant

Awarded by EY

Funding Acknowledgements

We thank the patient subjects for participating in this study. We also thank John Pater, Joanna Black, Jane Kelly, Sharon Freedman, Ivailo Tournev, and Sylvia Cherninkova for clinical input, Daniel Berner for sequencing assistance, and Veronica Ramirez, Ronnie Anderson, and Andrew Wei for technical assistance. Angpt1<SUP>GFP</SUP> mice were a gift from Sean Morrison, and Prox1<SUP>tdTomato</SUP> mice were a gift of Guillermo Oliver. This study was funded by NIH R01 HL124120 and R01 EY025799 (to SEQ); and NIH R01 EY014685, the Research to Prevent Blindness Inc. Lew R. Wasserman Award, and the University of Wisconsin Centennial Scholars Award (to TL Young). This work was also supported by grants from the March of Dimes Foundation and NEI P30EY014104 (to JLW), Howard Hughes Medical Center and EY 11721 (to SJ and KK), the Ophthalmic Research Institute of Australia, the Channel Seven Children's Research Foundation, the Department of Innovation, Industry, Science and Research (Australia), and the National Health and Medical Research Council of Australia. TS is supported by fellowship grants from the Japan Society for the Promotion of Science and Mallinckrodt Pharmaceuticals. Imaging was performed at the Northwestern University Center for Advanced Microscopy supported by NCI CCSG P30 CA060553 awarded to the Robert H. Lurie Comprehensive Cancer Center. This work was supported by the Northwestern University Transgenic and Targeted Mutagenesis Laboratory and a Cancer Center Support Grant (NCI CA060553). We also acknowledge support from Vision Core Grant NEI P30EY016665 and an unrestricted Research to Prevent Blindness grant of the University of Wisconsin-Madison Department of Ophthalmology and Visual Sciences.