Body mass index and breast cancer survival: A Mendelian randomization analysis

Q Guo; S Burgess; C Turman; MK Bolla; Q Wang; M Lush; J Abraham; K Aittomäki; IL Andrulis; C Apicella; V Arndt; M Barrdahl; J Benitez; CD Berg; C Blomqvist; SE Bojesen; B Bonanni; JS Brand; H Brenner; A Broeks; B Burwinkel; C Caldas; D Campa; F Canzian; J Chang-Claude; SJ Chanock; SF Chin; FJ Couch; A Cox; SS Cross; C Cybulski; K Czene; H Darabi; P Devilee; W Ryan Diver; AM Dunning; HM Earl; DM Eccles; AB Ekici; M Eriksson; DG Evans; PA Fasching; J Figueroa; D Flesch-Janys; H Flyger; SM Gapstur; MM Gaudet; GG Giles; G Glendon; M Grip; J Gronwald; L Haeberle; CA Haiman; P Hall; U Hamann; S Hankinson; JM Hartikainen; A Hein; L Hiller; FB Hogervorst; B Holleczek; MJ Hooning; RN Hoover; K Humphreys; DJ Hunter; A Hüsing; A Jakubowska; A Jukkola-Vuorinen; R Kaaks; M Kabisch; V Kataja; JA Knight; LB Koppert; VM Kosma; VN Kristensen; D Lambrechts; L Le Marchand; J Li; A Lindblom; S Lindström; J Lissowska; J Lubinski; MJ Machiela; A Mannermaa; S Manoukian; S Margolin; F Marme; JWM Martens; C McLean; P Menéndez; RL Milne; AM Mulligan; TA Muranen; H Nevanlinna; P Neven; SF Nielsen; BG Nordestgaard; JE Olson; JIA Perez; P Peterlongo

Journal article

Body mass index and breast cancer survival: A Mendelian randomization analysis

Q Guo, S Burgess, C Turman, MK Bolla, Q Wang, M Lush, J Abraham, K Aittomäki, IL Andrulis, C Apicella, V Arndt, M Barrdahl, J Benitez, CD Berg, C Blomqvist, SE Bojesen, B Bonanni, JS Brand, H Brenner, A Broeks Show all

International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2017

DOI: 10.1093/ije/dyx131

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Abstract

Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. Methods: We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separa..

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