Journal article

The RIO protein kinase-encoding gene Sj-riok-2 is involved in key reproductive processes in Schistosoma japonicum

Lu Zhao, Xin He, Christoph G Grevelding, Qing Ye, Ying Li, Robin B Gasser, Colette Dissous, Mudassar N Mughal, Yan-Qin Zhou, Jun-Long Zhao, Min Hu

PARASITES & VECTORS | BMC | Published : 2017

Abstract

BACKGROUND: Schistosomiasis is one of the most prevalent parasitic diseases worldwide and is caused by parasitic trematodes of the genus Schistosoma. The pathogenesis of schistosomiasis is caused by eggs whose production is the consequence of the pairing of schistosomes and the subsequent sexual maturation of the female. Previous studies have demonstrated that protein kinases are involved in processes leading to the male-induced differentiation of the female gonads, ovary and vitellarium. Right open reading frame protein kinase 2 (RIOK-2) is a member of the atypical kinase family and shown in other organisms to be responsible for ribosomal RNA biogenesis and cell-cycle progression, as well a..

View full abstract

Grants

Awarded by National Key Basic Research Program (973 Program) of China


Awarded by Fundamental Research Funds for the Central Universities


Awarded by National Natural Science Foundation


Awarded by Huazhong Agricultural University Scientific & Technological Self-innovation Foundation


Funding Acknowledgements

This study was supported by the National Key Basic Research Program (973 Program) of China (Grant No. 2015CB150300) and the Fundamental Research Funds for the Central Universities (Grant No. 2662015PY180) to MH, by the National Natural Science Foundation (Grant No. 31201897) to QY, and by Huazhong Agricultural University Scientific & Technological Self-innovation Foundation (Program No. 2015RC005) to RBG.