Transcription Factor IRF4 Promotes CD8( ) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection
Kevin Man, Sarah S Gabriel, Yang Liao, Renee Gloury, Simon Preston, Darren C Henstridge, Marc Pellegrini, Dietmar Zehn, Friederike Berberich-Siebelt, Mark A Febbraio, Wei Shi, Axel Kallies
Immunity | CELL PRESS | Published : 2017
Awarded by National Health and Medical Research Council of Australia
Awarded by Fritz Thyssen Stiftung
Awarded by Wilhelm Sander-Stiftung
We wish to thank Liana Mackiewicz, Carolina Alvarado, and Benjamin Lunz for expert technical support, and Stephen Nutt, Edgar Serfling, and Stefan Klein-Hessling for scientific discussion. We thank Anjana Rao, Laurie Glimcher, Pamela Ohashi, Tak Mak, Ulf Klein, Mark Chong, and Daniel Gray for mice. This work was supported by grants and fellowships from the National Health and Medical Research Council of Australia (project grants 1032850 and 1085151 to A.K., 1006592, 1045549, and 1065626 to M.P., 1023454 to W.S., Senior Research Fellowship 1021168 and Senior Principal Research Fellowship 1116936 to M.A.F.), the Walter and Eliza Hall Institute Centenary Fellowship funded by CSL (to W.S.), the Swiss National Science Foundation and the Novartis Foundation for Medical-Biological Research (fellowships to S.S.G.), and the Sylvia and Charles Viertel Foundation (Senior Medical Research Fellowships to A.K. and M.P.). Further funding was provided by the Fritz Thyssen Stiftung (10.13.2.215) and the Wilhelm Sander-Stiftung (2012.047.1) to F.B.-S. This study was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme.