Journal article

Oncogenes

JM Adams

Australian Journal of Biological Sciences | Published : 1984

Abstract

A barrage of information is now emerging about one of the thorniest and most significant problems in biology: the nature of the genetic events that trigger neoplasia. While the notion that cancer reflects somatic mutations is several decades old, only in the last few years could the relevant 'oncogenes' be identified and put to molecular dissection. The concept of oncogenes first solidified when the ability of tumourigenic viruses to induce experimental tumours in animals proved to reside in only one or two viral genes. Over the last five years, increasing evidence has accumulated that spontaneous tumours, including those of man, also reflect the action of only a few genes but, remarkably, t..

View full abstract

University of Melbourne Researchers