Objective speech marker correlates with clinical scores in non-dysarthric MS

Abstract

Background: Reduction of brain volume occurs in clinically active disease and correlates with progressive disability in multiple Sclerosis (MS). Although dysarthria is highly prevalent in MS, it only becomes clinically relevant in advanced stages of the disease. The relationship between early sub-clinical markers of dysarthria and overall disease severity is poorly understood. Aim: To examine the relationship between an objective marker of speech performance and validated clinical scores for disease severity in non-dysarthric subjects with relapsing-remitting and secondary progressive MS. Method: An experienced neurologist scored patients according to the Expanded Disability Status Scale..