Journal article

Quantitative Fundus Autofluorescence in Pseudoxanthoma Elasticum

Martin Gliem, Philipp L Mueller, Johannes Birtel, Myra B McGuinness, Robert P Finger, Philipp Herrmann, Doris Hendig, Frank G Holz, Peter Charbel Issa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2017

Abstract

Purpose: To quantify lipofuscin-associated fundus autofluorescence in patients with pseudoxanthoma elasticum (PXE), a model disease for Bruch's membrane pathology. Methods: In this prospective, monocenter, cross-sectional case-control study, 49 patients with PXE (mean age: 46 years, range 18-62) underwent quantitative fundus autofluorescence (qAF) imaging with a modified scanning laser ophthalmoscope containing an internal fluorescent reference for normalization of images. The mean qAF values of a circular ring centered on the fovea (qAF8) were measured and compared to 108 healthy controls (mean age 40 years, range 18-64). Results: Overall, patients with PXE showed lower qAF8 values compared..

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Grants

Awarded by BONFOR research program of the University of Bonn, Bonn, Germany


Awarded by National Health and Medical Research Council (NHMRC) Centre for Clinical Research Excellence Grant, Canberra, Australia


Funding Acknowledgements

Supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC); ProRetina Deutschland, Aachen, Germany; the BONFOR research program of the University of Bonn, Bonn, Germany (O-137.0018); and the National Health and Medical Research Council (NHMRC) Centre for Clinical Research Excellence Grant #529923, Canberra, Australia. The Department of Ophthalmology, University of Bonn, receives research support from Heidelberg Engineering. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government. The authors alone are responsible for the content and writing of the paper. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.