Journal article

Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies

Yow Keat Tham, Kevin Huynh, Natalie A Mellett, Darren C Henstridge, Helen Kiriazis, Jenny YY Ooi, Aya Matsumoto, Natalie L Patterson, Junichi Sadoshima, Peter J Meikle, Julie R McMullen

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | ELSEVIER SCIENCE BV | Published : 2018

Abstract

Cardiac myocyte membranes contain lipids which remodel dramatically in response to heart growth and remodeling. Lipid species have both structural and functional roles. Physiological and pathological cardiac remodeling have very distinct phenotypes, and the identification of molecular differences represent avenues for therapeutic interventions. Whether the abundance of specific lipid classes is different in physiological and pathological models was largely unknown. The aim of this study was to determine whether distinct lipids are regulated in settings of physiological and pathological remodeling, and if so, whether modulation of differentially regulated lipids could modulate heart size and ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Funding Acknowledgements

This study was funded by National Health and Medical Research Council Project Grant (APP1045585 to J.R.M) and also supported in part by the Victorian Government Operational Infrastructre Support program. P.J.M. and J.R.M are National Health and Medical Research Council Senior Research Fellows (IDs 1042095, 586604, 1078985). J.R.M was also supported by an Australian Research Council Future Fellowship (FT0001657). K.H was supported jointly by an Alzheimer's Australia Dementia Research Foundation Scholarship and Baker Heart and Diabetes Institute Postgraduate Scholarship. Y.K.T was supported by an Australian Postgraduate Award and Baker Heart and Diabetes Institute Top up Stipend.