Natural killer cells and anti-tumor immunity
Sandra E Nicholson, Narelle Keating, Gabrielle T Belz
MOLECULAR IMMUNOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Immune checkpoint inhibitors harness the power of the immune system to fight cancer. The clinical success achieved with antibodies against the inhibitory T cell receptors PD-1 and CTLA4 has focused attention on the possibility of manipulating other immune cells, in particular those involved in innate immunity. Here we review the role of innate lymphoid cells (ILCs) and their contribution to tumor immunity. As the prototypical ILC, the natural killer (NK) cell has an intrinsic ability to detect and kill cancer cells. NK cells are dependent on the cytokine interleukin (IL)-15 for their development and effector activity. We discuss the role of the Suppressor of cytokine (SOCS) proteins in negat..View full abstract
Awarded by Elizabeth Blackburn NHMRC Fellowship
Awarded by NHMRC IRIISS
GTB is supported by an Elizabeth Blackburn NHMRC Fellowship (#516711). The authors were supported in part by an NHMRC IRIISS grant 361646 and a Victorian State Government Operational Infrastructure Scheme grant.