Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Phillip P Sharp; Jean-Marc Garnier; Tamas Hatfaludi; Zhen Xu; David Segal; Kate E Jarman; Helene Jousset; Alexandra Garnham; John T Feutrill; Anthony Cuzzupe; Peter Hall; Scott Taylor; Carl R Walkley; Dean Tyler; Mark A Dawson; Peter Czabotar; Andrew F Wilks; Stefan Glaser; David CS Huang; Christopher J Burns

Journal article

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Phillip P Sharp, Jean-Marc Garnier, Tamas Hatfaludi, Zhen Xu, David Segal, Kate E Jarman, Helene Jousset, Alexandra Garnham, John T Feutrill, Anthony Cuzzupe, Peter Hall, Scott Taylor, Carl R Walkley, Dean Tyler, Mark A Dawson, Peter Czabotar, Andrew F Wilks, Stefan Glaser, David CS Huang, Christopher J Burns

ACS Medicinal Chemistry Letters | AMER CHEMICAL SOC | Published : 2017

DOI: 10.1021/acsmedchemlett.7b00389

University of Melbourne Researchers

Mark Dawson Author The Sir Peter MacCallum Department of Oncology

Carl Walkley Author Medicine - St Vincent's Hospital

Peter Czabotar Author Medical Biology (W.E.H.I.)

Helene Jousset Sabroux Author Medical Biology (W.E.H.I.)

Alexandra Garnham Author Medical Biology (W.E.H.I.)

Grants

Funding Acknowledgements

Our work is supported by the NHMRC (fellowship to P.E.C.) and the Victorian State Government Operational Infrastructure Support, and the Australian Government NHMRC IRIISS.