Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Bruce CV Campbell; Wim H van Zwam; Mayank Goyal; Bijoy K Menon; Diederik WJ Dippel; Andrew M Demchuk; Serge Bracard; Philip White; Antoni Davalos; Charles BLM Majoie; Aad van der Lugt; Gary A Ford; Natalia Perez de la Ossa; Michael Kelly; Romain Bourcier; Geoffrey A Donnan; Yvo BWEM Roos; Oh Young Bang; Raul G Nogueira; Thomas G Devlin; Lucie A van den Berg; Frederic Clarencon; Paul Burns; Jeffrey Carpenter; Olvert A Berkhemer; Dileep R Yavagal; Vitor Mendes Pereira; Xavier Ducrocq; Anand Dixit; Helena Quesada; Jonathan Epstein; Stephen M Davis; Olav Jansen; Marta Rubiera; Xabier Urra; Emilien Micard; Hester F Lingsma; Olivier Naggara; Scott Brown; Francis Guillemin; Keith W Muir; Robert J van Oostenbrugge; Jeffrey L Saver; Tudor G Jovin; Michael D Hill; Peter J Mitchell

Journal article

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Bruce CV Campbell, Wim H van Zwam, Mayank Goyal, Bijoy K Menon, Diederik WJ Dippel, Andrew M Demchuk, Serge Bracard, Philip White, Antoni Davalos, Charles BLM Majoie, Aad van der Lugt, Gary A Ford, Natalia Perez de la Ossa, Michael Kelly, Romain Bourcier, Geoffrey A Donnan, Yvo BWEM Roos, Oh Young Bang, Raul G Nogueira, Thomas G Devlin Show all

LANCET NEUROLOGY | ELSEVIER SCIENCE INC | Published : 2018

DOI: 10.1016/S1474-4422(17)30407-6

Abstract

BACKGROUND: General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. METHODS: For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombe..

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