Journal article
Heat shock proteins as modulators and therapeutic targets of chronic disease: An integrated perspective
AL Edkins, JT Price, A Graham Pockley, GL Blatch
Philosophical Transactions of the Royal Society B Biological Sciences | ROYAL SOC | Published : 2018
Abstract
Many heat shock proteins (HSPs) are essential to survival as a consequence of their role as molecular chaperones, and play a critical role in maintaining cellular proteostasis by integrating the fundamental processes of protein folding and degradation. HSPs are arguablyamong the most prominent classes of proteins that have been broadly linked to many human disorders, with changes in their expression profile and/or intracellular/extracellular location now being described as contributing to the pathogenesis of a numberof different diseases. Although the concept was initially controversial, it is now widely accepted that HSPs have additional biological functions over and above their role in pro..
View full abstractGrants
Awarded by Treasury
Funding Acknowledgements
G.L.B. is funded by the National Research Foundation (NRF, South Africa, grant no. 68881) and The University of Notre Dame Australia (UNDA). A.L.E. is funded by the South African Research Chairs Initiative of the Department of Science and Technology (DST) and the NRF (grant no. 98566), NRF CPRR and Incentive funding (grant nos 91523, 90641), the Cancer Association of South Africa (CANSA), the Medical Research Council South Africa (MRC-SA) with funds from the National Treasury under its Economic Competitiveness and Support Package, and Rhodes University. A.G.P. is currently funded by the John and Lucille van Geest Foundation, the Headcase Cancer Trust, the Roger Counter Foundation, the National Institute for Health Research (NIHR), NanoString Technologies Inc. and the Qatar National Research Fund. J.T.P. is funded by Victoria University, Stop the Mets, an Australian Institute for Musculoskeletal Science Seed grant and a National Health and Medical Research Council (NHMRC) Project grant (GRNT1057706).