Mononuclear palladium(II) and platinum(II) complexes of P,C-donor ligands: Synthesis, crystal structures, cytotoxicity, and mechanistic studies of a highly stereoselective Mizoroki-Heck reaction

Abstract

Cyclometalated Pd(ii) and Pt(ii) complexes of unsymmetrical phosphonium ylides Ph2P(CH2)nPPh2C(H)C(O)C6H4R (R = Ph, n = 2 (Y1); R = NO2, n = 1 (Y2)) have been prepared through a simple procedure to explore new directions in stereoselective catalysis and antitumor metallodrugs. The new pallada-and platinacycle complexes have been characterized by spectroscopic, crystallographic, and density functional theory methods. Catalytic activity and in vitro cytotoxicity of these compounds, as assessed, respectively, using the Mizoroki-Heck reaction and a human tumor cell line, have been evaluated. In particular, a mechanistic pathway of the Heck reaction catalyzed by Pd(ii) complex (1) with a chelatin..