Journal article
Predicting response after infliximab salvage in acute severe ulcerative colitis
MC Choy, D Seah, A Gorelik, YK An, CY Chen, FA Macrae, MP Sparrow, WR Connell, GT Moore, G Radford-Smith, DR Van Langenberg, P De Cruz
Journal of Gastroenterology and Hepatology Australia | WILEY | Published : 2018
DOI: 10.1111/jgh.14072
Abstract
Background and Aim: Acute severe ulcerative colitis (ASUC) is a medical emergency requiring prompt therapeutic intervention. Although infliximab has been used as salvage therapy for over 15 years, clinical predictors of treatment success are lacking. We performed a retrospective analysis to identify factors that predict colectomy and may guide dose intensification. Methods: Fifty-four hospitalized patients received infliximab for ASUC at seven Australian centers (April 2014–May 2015). Follow-up was over 12 months. The data were primarily analyzed for predictors of colectomy. Accelerated (AI) versus standard (SI) infliximab induction strategies were also compared. Results: Of 54 patients iden..
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Funding Acknowledgements
This work was supported by an Australian Postgraduate Award scholarship from the University of Melbourne (M. C. C.), David Bickart Clinician Research Award from the University of Melbourne (P. D. C.) and Bushell Postdoctoral Award from the Gastroenterological Society of Australia (P. D. C.).