Journal article

The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy

Elizabeth Vincan, Renate HM Schwab, Dustin J Flanagan, Jean M Moselen, Bang M Tran, Nick Barker, Toby J Phesse, J Larrain (ed.), G Olivares (ed.)

WNT SIGNALING IN HEALTH AND DISEASE | ELSEVIER ACADEMIC PRESS INC | Published : 2018

Abstract

The Wnt pathway is at the heart of organoid technology, which is set to revolutionize the cancer field. We can now predetermine a patient's response to any given anticancer therapy by exposing tumor organoids established from the patient's own tumor. This cutting-edge biomedical platform translates to patients being treated with the correct drug at the correct dose from the outset, a truly personalized and precise medical approach. A high throughput drug screen on organoids also allows drugs to be tested in limitless combinations. More recently, the tumor cells that are resistant to the therapy given to a patient were selected in culture using the patient's organoids. The resistant tumor org..

View full abstract