Vancomycin dosing in chronic high-flux haemodialysis: a systematic review

Abstract

The aim of this study was to systematically evaluate whether non-weight-based dosing (non-WBD) or weight-based dosing (WBD) of vancomycin leads to a higher proportion of patients achieving the pharmacokinetic/pharmacodynamic target. Studies from January 1985 to February 2017 were identified through Cochrane, MEDLINE and Embase databases. Those conducted in adults with end-stage renal disease receiving high-flux haemodialysis (HD) and intravenous vancomycin were included. The primary outcome was the proportion of patients with a pre-HD vancomycin concentration of 15–20 mg/L and/or an area under the concentration–time curve/minimum inhibitory concentration (AUC/MIC) ratio ≥400. Of the 3948 stu..