Journal article
Nationwide genetic surveillance of Plasmodium vivax in Papua New Guinea reveals heterogeneous transmission dynamics and routes of migration amongst subdivided populations
AA Fola, E Nate, GL Abby Harrison, C Barnadas, MW Hetzel, J Iga, P Siba, I Mueller, AE Barry
Infection Genetics and Evolution | ELSEVIER | Published : 2018
Abstract
The Asia Pacific Leaders in Malaria Alliance (APLMA) have committed to eliminate malaria from the region by 2030. Papua New Guinea (PNG) has the highest malaria burden in the Asia-Pacific region but with the intensification of control efforts since 2005, transmission has been dramatically reduced and Plasmodium vivax is now the dominant malaria infection in some parts of the country. To gain a better understanding of the transmission dynamics and migration patterns of P. vivax in PNG, here we investigate population structure in eight geographically and ecologically distinct regions of the country. A total of 219 P. vivax isolates (16–30 per population) were successfully haplotyped using 10 m..
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Awarded by Global Fund to Fight AIDS, Tuberculosis and Malaria
Funding Acknowledgements
The authors are very grateful to Papua New Guinean communities particularly the volunteers and their families for providing blood samples during the survey. We would like to thank staff of the Papua New Guinea Institute of Medical Research for their generous ongoing support, especially the field researchers who conducted the nationwide survey, the microscopy team and the laboratory team who performed DNA extraction and malaria molecular diagnosis on these samples. We also acknowledge the assistance from the National Department of Health, in particular L. Makita. This study was made possible through a National Health and Medical Research Council of Australia Project Grant Number GNT1027108. Funding for sample collection was provided by the Global Fund to Fight AIDS, Tuberculosis and Malaria. The authors acknowledge the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme.