Journal article
Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model
JT Pearson, M Yoshimoto, YC Chen, R Sultani, AJ Edgley, H Nakaoka, M Nishida, K Umetani, MT Waddingham, HL Jin, Y Zhang, DJ Kelly, DO Schwenke, T Inagaki, H Tsuchimochi, I Komuro, S Yamashita, M Shirai
Scientific Reports | NATURE PORTFOLIO | Published : 2017
Abstract
Reduced clearance of lipoproteins by HDL scavenger receptor class B1 (SR-B1) plays an important role in occlusive coronary artery disease. However, it is not clear how much microvascular dysfunction contributes to ischemic cardiomyopathy. Our aim was to determine the distribution of vascular dysfunction in vivo in the coronary circulation of male mice after brief exposure to Paigen high fat diet, and whether this vasomotor dysfunction involved nitric oxide (NO) and or endothelium derived hyperpolarization factors (EDHF). We utilised mice with hypomorphic ApoE lipoprotein that lacked SR-B1 (SR-B1-/-/ApoER61h/h, n = 8) or were heterozygous for SR-B1 (SR-B1+/-/ApoER61h/h, n = 8) to investigate ..
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Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
Experiments were performed at the Japan Synchrotron Radiation Research Institute (SPring-8, BL28B2, Proposals 2011B1588 and 2012A1674). The work was supported by an Intramural Research Grant of the NCVC (27-2-2) to M.S. and J.T.P.