Journal article

Mitochondrial modifying nutrients in treating chronic fatigue syndrome: A 16-week open-label pilot study

Ranjit Menon, Lachlan Cribb, Jenifer Murphy, Melanie M Ashton, Georgina Oliver, Nathan Dowling, Alyna Turner, Olivia Dean, Michael Berk, Chee H Ng, Jerome Sarris



Introduction: Recent evidence suggests that mitochondrial dysfunction may play a role in the pathophysiology of chronic fatigue syndrome (CFS). We undertook a pilot investigation of a combination of nutraceutical nutrient compounds which are involved in mitochondrial function and energy generation, to assess their efficacy in improving symptoms of CFS. An open-label design was employed as CFS is largely treatment-resistant with limited placebo-response. Methods: A 16-week open-label trial of a nutraceutical combination (primary nutrients: Coenzyme Q10, Alpha lipoic acid, Acetyl-L-carnitine, N-acetyl cysteine, B Vitamins, in addition to co-factors) was undertaken in ten patients with CFS. Fat..

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Awarded by NHMRC Clinical Research Fellowship

Awarded by NHMRC Senior Principal Research Fellowship

Funding Acknowledgements

BioCeuticals (R) generously supplied the investigational product (they were completely uninvolved in the study's design, conduct, data analysis, and publication writing). JS is funded by an NHMRC Clinical Research Fellowship (APP1125000). MB is supported by a NHMRC Senior Principal Research Fellowship (GNT1059660).