Oral trivalent bismuth ions decrease, and trivalent indium or ruthenium ions increase, intestinal tumor burden in Apc(Delta 14/ ) mice
Marie Laval, Chelsea Dumesny, Mal Eutick, Graham S Baldwin, Kathryn M Marshall
METALLOMICS | ROYAL SOC CHEMISTRY | Published : 2018
Immature forms of the peptide hormone gastrin have been implicated in the development of colorectal cancer (CRC). The biological activity of glycine-extended gastrin (Ggly) is dependent on the binding of Fe3+ ions in vitro and in vivo. The aim of the present study was to determine the effect of blocking Fe3+ ion binding to Ggly, using Bi3+, In3+ or Ru3+ ions, on the development of intestinal tumors in APCΔ14/+ mice. APCΔ14/+ mice were treated orally with Bi3+, In3+ or Ru3+ ions for up to 60 days, serum trace metals were analyzed by inductively coupled plasma mass spectrometry, and the incidence and size of intestinal tumors were assessed. Bi3+ treatment significantly decreased the number of ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
We thank Jennifer Hunt for preparation of the metal ion solutions and Dannel Yeo for invaluable assistance with the survival statistics. This work was supported by the National Health and Medical Research Council of Australia [grant number 1020983 to GSB].