Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe
Laura E Edgington, Martijn Verdoes, Alberto Ortega, Nimali P Withana, Jiyoun Lee, Salahuddin Syed, Michael H Bachmann, Galia Blum, Matthew Bogyo
Journal of the American Chemical Society | AMER CHEMICAL SOC | Published : 2013
Awarded by National Insittutes of Health
This work was supported by a grant from the National Insittutes of Health (R01 EB005011 to MB). The authors would like to thank M. Abrahamson for the kind gift of recombinant Cystatin C mutants. We also thank T. Doyle at the Stanford Small Animal Facility for assistance with the optical imaging studies. Lastly, we thank S. Lynch at the Stanford NMR Facility and A. Chien and T. McLaughlin at the Stanford Mass Spec Facility for their assistance with detailed compound characterization.