Journal article

A Nonpeptidic Cathepsin S Activity-Based Probe for Noninvasive Optical Imaging of Tumor-Associated Macrophages

Martijn Verdoes, Laura E Edgington, Ferenc A Scheeren, Melissa Leyva, Galia Blum, Kipp Weiskopf, Michael H Bachmann, Jonathan A Ellman, Matthew Bogyo

Chemistry & Biology | CELL PRESS | Published : 2012

Grants

Awarded by National Institutes of Health


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

We thank J. Lee for help with synthesis, A. W. Pun for assistance with macrophage isolation, and M. A. Child and E. Due for critical discussions. We also thank T. Doyle at the Stanford Small Animal Facility at Stanford for assistance with optical imaging studies and S. R. Lynch at the Stanford University Department of Chemistry NMR facility for assistance. This work was supported by the National Institutes of Health (grants R01 EB005011 and R01 AI078947 to M.B.). M.V. is supported by a Rubicon fellowship from the Netherlands Organization for Scientific Research (NWO).