An Optimized Activity-Based Probe for the Study of Caspase-6 Activation
Laura E Edgington, Bram J van Raam, Martijn Verdoes, Christoph Wierschem, Guy S Salvesen, Matthew Bogyo
Chemistry & Biology | CELL PRESS | Published : 2012
Awarded by NIH
We thank D. Ehrnhoefer, N. Skotte, and M. Hayden of the University of British Columbia for critical discussions of caspase-6 biology, C. Pop, formerly of the Sanford-Burnham Medical Research Institute, for helpful advice on the enzyme kinetics experiments, and S. Snipas for his help in cloning the caspase-6 mutants. We also thank T. Doyle at the Stanford Small Animal Facility for assistance with the optical imaging studies. This work was supported by a grant from the NIH (R01 EB005011). B.J.v.R. and M.V. are supported by a Rubicon fellowship from the Netherlands Organization for Scientific Research, and B.J.v.R. by an additional fellowship from the Barth Syndrome Foundation.