Journal article
Safety and immunogenicity of onderstepoort biological products’ rift valley fever clone 13 vaccine in sheep and goats under field conditions in senegal
MM Lo, V Mbao, P Sierra, Y Thiongane, M Diop, M Donadeu, B Dungu
Onderstepoort Journal of Veterinary Research | ONDERSTEPOORT VETERINARY INST, AGRICULTURAL RESEARCH COUNCIL | Published : 2015
Abstract
This blinded field safety study was conducted in Senegal to assess safety and immunogenicity of administration of the registered dose of Rift Valley fever virus (RVFV) Clone 13 vaccine (Onderstepoort Biological Products) to sheep and goats of West African breeds under natural conditions. A total of 267 small ruminants (220 sheep, 47 goats) were included; half received RVFV Clone 13 vaccine at the recommended dose and half received the diluent (as placebo) only. The study was performed on three commercial farms in the northern and eastern region of Senegal in accordance with veterinary good clinical practices. The animals were observed daily for 3 days after vaccination, and then weekly for 1..
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Funding Acknowledgements
The authors are grateful to all the technicians at LNERV, ISRA, Dakar as well as Ismaila Seck, field veterinary at Mpal, Maniang Diokh field veterinary at Thille Boubacar and Serigne Mbaye field veterinary at Diawara for their valuable contribution to the study. This work was funded by the Bill & Melinda Gates Foundation & the UK Government's Department for International Development (DFID).