Journal article
Randomized Controlled Field Trial to Assess the Immunogenicity and Safety of Rift Valley Fever Clone 13 Vaccine in Livestock
MK Njenga, L Njagi, SM Thumbi, S Kahariri, J Githinji, E Omondi, A Baden, M Murithi, J Paweska, PM Ithondeka, KJ Ngeiywa, B Dungu, M Donadeu, PM Munyua
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2015
Abstract
Background: Although livestock vaccination is effective in preventing Rift Valley fever (RVF) epidemics, there are concerns about safety and effectiveness of the only commercially available RVF Smithburn vaccine. We conducted a randomized controlled field trial to evaluate the immunogenicity and safety of the new RVF Clone 13 vaccine, recently registered in South Africa. Methods: In a blinded randomized controlled field trial, 404 animals (85 cattle, 168 sheep, and 151 goats) in three farms in Kenya were divided into three groups. Group A included males and non-pregnant females that were randomized and assigned to two groups; one vaccinated with RVF Clone 13 and the other given placebo. Grou..
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Funding Acknowledgements
Funding for this project was provided by the Global Alliance for Livestock Veterinary Medicines (GALVMed) and United States' Centers for Disease Control and Prevention (CDC). Whereas the input of the GALVMed scientists was sought in the study design and manuscript writing, they were not involved in the data collection or analysis.