Journal article

Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs

Luis Alvarez, Carlos Saumell, Luis Fuse, Laura Moreno, Laura Ceballos, Gilbert Domingue, Meritxell Donadeu, Baptiste Dungu, Carlos Lanusse

Veterinary Parasitology | ELSEVIER SCIENCE BV | Published : 2013


The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n=12 each), respectively. Each experiment involved two different groups (n=6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ ..

View full abstract


Funding Acknowledgements

The authors would like to acknowledge Merial, France, who kindly provided the OFZ formulation (Synanthic (R), OFZ 9.06%) used in the current work. We also thank the Department for International Development (DFID) UK and the Bill and Melinda Gates Foundation (BMGF) whose joint funding facilitated the sponsorship of these GCP studies by GALVmed (Global Alliance for Veterinary Medicines).