Journal article

Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs

Jenna M Reps, Jonathan M Garibaldi, Uwe Aickelin, Daniele Soria, Jack E Gibson, Richard B Hubbard

Drug Safety | Springer Verlag | Published : 2014

Abstract

Background: Children are frequently prescribed medication `off-label', meaning there has not been sufficient testing of the medication to determine its safety or effectiveness. The main reason this safety knowledge is lacking is due to ethical restrictions that prevent children from being included in the majority of clinical trials. Methods: Multiple measures of association are calculated for each drug and medical event pair and these are used as features that are fed into a classifier to determine the likelihood of the drug and medical event pair corresponding to an adverse drug reaction. The classifier is trained using known adverse drug reactions or known non-adverse drug reaction re..

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University of Melbourne Researchers

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Funding Acknowledgements

This study was funded by the Department of Computer Sciences, University of Nottingham, UK. J.M. Reps, J.M. Garibaldi, U. Aickelin, D. Soria, J.E. Gibson and R. B. Hubbard have no conflicts of interest that are directly relevant to the content of this study.