Influence of anterior midcingulate cortex on drinking behavior during thirst and following satiation
Pascal Saker, Michael J Farrell, Gary F Egan, Michael J McKinley, Derek A Denton
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2018
In humans, activity in the anterior midcingulate cortex (aMCC) is associated with both subjective thirst and swallowing. This region is therefore likely to play a prominent role in the regulation of drinking in response to dehydration. Using functional MRI, we investigated this possibility during a period of "drinking behavior" represented by a conjunction of preswallow and swallowing events. These events were examined in the context of a thirsty condition and an "oversated" condition, the latter induced by compliant ingestion of excess fluid. Brain regions associated with swallowing showed increased activity for drinking behavior in the thirsty condition relative to the oversated condition...View full abstract
This work was supported by the G. Harold and Leila Y. Mathers Charitable Foundation, the Search Foundation, S. Baillieu Myer, Diana Gibson, Robert Albert, Dr. Mark Nelson, Tim Jones, Marcus Besen, and Jeanne Pratt.