Journal article

Innate immune genes in persistent mating-induced endometritis in horses

CD Marth, SM Firestone, D Hanlon, LY Glenton, GF Browning, ND Young, N Krekeler

Reproduction Fertility and Development | CSIRO Publishing | Published : 2017


© CSIRO 2018. Persistent mating-induced endometritis (PMIE) severely decreases fertility in horses. The aim of the present study was to evaluate differences between horses susceptible to PMIE and a control group in terms of the expression of selected immune response and effector genes, and the effects of oestrous cycle stage on this expression. Endometrial biopsies from 18 uterine samples of mares in the control group (eight in dioestrus, 10 in oestrus) and 16 PMIE-susceptible mares (four in dioestrus, 12 in oestrus) were analysed by quantitative real-time reverse transcription-polymerase chain reaction. Genes for pathogen recognition receptors Toll-like receptor 2 (TLR2) and NLR family CARD..

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Funding Acknowledgements

The authors thank Faye Docherty and Paul Bennet for their help with the production of histology slides and the Gluck Institute at the University of Kentucky for allowing us access to tissues from their research mares. This work was supported by funds from an Early Career Research Grant provided by The University of Melbourne. Neil Young holds an National Health and Medical Research Council (NHMRC) of Australia Career Development Fellowship. Simon Firestone is supported by an Australian Research Council (ARC) Discovery Early Career Research Award.