Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

Grants

Funding Acknowledgements

We thank J. Newman from the Commonwealth Scientific and Industrial Research Organization Collaborative Crystallization Centre for assistance with setting up the crystallization screens, the Walter and Eliza Hall Institute's Monoclonal Antibody Facility for production of antibodies, J. Williamson for assistance with mass spectrometry, and MX and SAXS beamline staff at the Australian Synchrotron for their assistance during data collection. We thank F. Nosten, the staff and patients attending the Mae Sot Malaria Clinic in Thailand, and clinics associated with the Shoklo Malaria Research Unit (SMRU), Tak Province, Thailand. We also thank Y. Colin and O. S. Bertrand (INSERM/University Paris 7) for the generous gift of the antibodies to DARC. W.-H.T. is a Howard Hughes Medical Institute-Wellcome Trust International Research Scholar (208693/Z/17/Z). This work was supported in part by the Australian Research Council Future Fellowships to W.-H.T. and M.D.W.G., a Speedy Innovation Grant to W.-H.T., and a National Health and Medical Research Council fellowship (1105754) to J.M.M. U.K. was supported by a Canadian Institutes of Health Research Postdoctoral Fellowship. R.D.P. is funded by Wellcome Trust 090770. M.P.W. was supported by a Wellcome Trust Senior Clinical Research Fellowship (108070/Z/15/Z). This study received funding from Singapore National Medical Research Council (NMRC) (NMRC/CBRG/0047/2013) and the Agency for Science, Technology and Research (A*STAR, Singapore). SMRU is sponsored by The Wellcome Trust of Great Britain as part of the Oxford Tropical Medicine Research Programme of Wellcome Trust-Mahidol University. Work in the M.T.D. laboratory was supported by National Institutes of Health grant 1R01HL139337. We also acknowledge the support of the B.R. laboratory from the Marsden Fund 17-UOO-241. The authors acknowledge the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme. All data and code to understand and assess the conclusions of this research are available in the main text, supplementary materials, and via the following repositories: The atomic coordinates and structure factors for PvRBP2b have been deposited in PDB with accession number 5W53. Genotypes were derived from sequence data generated at the Wellcome Trust Sanger Institute (Wellcome Trust 206194 and 098051).