Journal article
Amyloid burden and incident depressive symptoms in preclinical Alzheimer's disease
S Perin, KD Harrington, YY Lim, K Ellis, D Ames, RH Pietrzak, A Schembri, S Rainey-Smith, O Salvado, SM Laws, RN Martins, VL Villemagne, CC Rowe, CL Masters, P Maruff
Journal of Affective Disorders | ELSEVIER | Published : 2018
Abstract
Background: Relationships between depression and Alzheimer's disease (AD) may become clearer if studied in preclinical AD where dementia is not present. Method: The aim of this study was to evaluate prospectively, relationships between brain amyloid-β (Aβ), depressive symptoms and screen positive depression in cognitively normal (CN) older adults. Depressive symptoms were measured with the Geriatric Depression Inventory (GDS-15) in CN adults from the Australian Imaging Biomarkers and Lifestyle (AIBL) study without depression at baseline and classified as having abnormally high (Aβ+; n = 136) or low (Aβ−; n = 449) Aβ according to positron emission tomography at 18-month intervals over 72 mont..
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Funding Acknowledgements
Funding for the study was provided in part by the study partners (Australian Commonwealth Scientific Industrial and Research Organization [CSIRO], Edith Cowan University [ECU], Mental Health Research Institute [MHRI], Alzheimer's Australia [AA], National Ageing Research Institute [NARI], Austin Health, CogState Ltd., Hollywood Private Hospital, Sir Charles Gardner Hospital). The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as ongoing funding from the Science and Industry Endowment Fund (SIEF). The authors also acknowledge the financial support of the Cooperative Research Centre (CRC) for Mental Health, from the Australian Government.