Journal article
Cost-effectiveness and comparative effectiveness of cancer risk management strategies in BRCA1/2 mutation carriers: a systematic review
L Petelin, AH Trainer, G Mitchell, D Liew, PA James
Genetics in Medicine | ELSEVIER SCIENCE INC | Published : 2018
DOI: 10.1038/gim.2017.255
Abstract
Purpose: To review the evidence for the effectiveness and cost-effectiveness of cancer risk management interventions for BRCA carriers. Methods: Comparative effectiveness and cost-effectiveness analyses were identified by searching scientific and health economic databases. Eligible studies modeled the impact of a cancer risk management intervention in BRCA carriers on life expectancy (LE), cancer incidence, or quality-adjusted life years (QALYs), with or without costs. Results: Twenty-six economic evaluations and eight comparative effectiveness analyses were included. Combined risk-reducing salpingo-oophorectomy and prophylactic mastectomy resulted in the greatest LE and was cost-effective i..
View full abstractGrants
Funding Acknowledgements
This work is carried out with support from the Inherited Cancer Connect (ICCon) Partnership. The ICCon Partnership is funded by the Cancer Council New South Wales Strategic Research Partnership (STREP) scheme. L.P. is supported through an Australian Government Research Training Program Scholarship. The funders had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.