Emerging Roles for VEGF-D in Human Disease
Steven A Stacker, Marc G Achen
BIOMOLECULES | MDPI | Published : 2018
Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide variety of prevalent diseases in humans. Vascular endothelial growth factor-D (VEGF-D) is a secreted protein that can promote the remodeling of blood vessels and lymphatics in development and disease. Recent fundamental and translational studies have provided insight into the molecular mechanisms by which VEGF-D exerts its effects in human disease. Hence this protein is now of interest as a therapeutic and/or diagnostic target, or as a potential therapeutic agent, in a diversity of indications in cardiovascular medicine, cancer and the devastating pulmonary condi..View full abstract
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S.A.S. and M.G.A. have been supported by Program Grants, Project Grants and Senior Research Fellowships from the National Health and Medical Research Council of Australia.