Journal article

Co-morbid depressive disorder is associated with better neurocognitive performance in first episode schizophrenia spectrum

Sarah E Herniman, Sue M Cotton, Eoin Killackey, Robert Hester, Kelly A Allott

Journal of Affective Disorders | ELSEVIER SCIENCE BV | Published : 2018


BACKGROUND: Both major depressive disorder (MDD) and first episode schizophrenia spectrum (FES) are associated with significant neurocognitive deficits. However, it remains unclear whether the neurocognitive deficits in individuals with FES are more severe if there is comorbid depressive disorder. The aim of this study was to compare the neurocognitive profiles between those with and without full-threshold depressive disorder in FES. METHOD: This study involved secondary analysis of baseline data from a randomized controlled trial of vocational intervention for young people with first-episode psychosis (N = 82; age range: 15-25 years). RESULTS: Those with full-threshold depressive disorder (..

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Awarded by Australian Research Council

Awarded by National Health and Medical Research Council Career Development Fellowship

Funding Acknowledgements

This work was supported by Australian Rotary Health; The Australian Research Council (LP0883273); Orygen Youth Health Research Centre; a University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences Ronald Philip Griffiths Fellowship to Kelly Allott; and a National Health and Medical Research Council Career Development Fellowship to Eoin Killackey (#1051891) and Sue Cotton (#1061998). All funding sources had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.