Journal article
Cardiometabolic health among adult offspring of hypertensive pregnancies: The cardiovascular risk in young finns study
RJ Tapp, AD Hughes, M Kähönen, TY Wong, N Witt, T Lehtimäki, N Hutri-Kähönen, P Sahota, M Juonala, OT Raitakari
Journal of the American Heart Association | WILEY | Published : 2018
Abstract
Background--Cardiometabolic health among adult offspring of hypertensive disorders of pregnancy (HDP) is relatively unknown. We hypothesized that offspring of HDP would have abnormalities in the retinal microvasculature and cardiac structure by midadulthood. Methods and Results--The Cardiovascular Risk in Young Finns Study included randomly selected children from 5 Finnish university cities. The mean age of participants was 40 years (range 34-49 years) at the time of retinal photography and cardiac assessment. Offspring born ≥ 37 weeks of gestation and appropriate for gestational age (n=1006) were included. Offspring of HDP had higher systolic blood pressure (β=4.68, P < 0.001), body mass in..
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Awarded by Seventh Framework Programme
Funding Acknowledgements
The Young Finns Study has been financially supported by the Academy of Finland: grants 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117797 (Gendi), 41071 (Skidi), and 286284, the Social Insurance Institution of Finland, Kuopio, Tampere and Turku University Hospital Medical Funds, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research and Finnish Cultural Foundation, Tampere Tuberculosis Foundation, and Emil Aaltonen Foundation. Hughes received support from a Biomedical Research Centre Award to University College London Hospital and from the British Heart Foundation (CS/15/6/31468, PG/12/29/29497).