Comparative study of novel in situ decorated porous chitosan-selenium scaffolds and porous chitosan-silver scaffolds towards antimicrobial wound dressing application
Dhee P Biswas, Neil M O'Brien-Simpson, Eric C Reynolds, Andrea J O'Connor, Phong A Tran
JOURNAL OF COLLOID AND INTERFACE SCIENCE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018
Dermal defects caused by trauma or disease are challenging to treat due to difficult-to-treat infections that impair wound healing. Due to the widespread emergence of drug-resistant bacteria and dwindling discoveries of new antibiotics, there is currently an urgent need to introduce novel antimicrobials effective against antibiotic-resistant bacteria without causing damage to host tissues. As selenium (Se) and silver (Ag) are known for their antimicrobial properties, we investigated the separate loading of these materials into porous chitosan/PVA (CS) scaffolds through a simple in situ deposition method to create two distinct wound dressing materials (CS-Se and CS-Ag). Scaffolds with Se nano..View full abstract
The authors thank Roger Curtain from the Bio21 Advanced Microscopy Facility (the University of Melbourne) for help with SEM imaging. We would also like to thank the Particulate Fluids Processing Centre (PFPC) and the Oral Health CRC at the Melbourne Dental School for access to infrastructure and equipment. DB gratefully acknowledges the Australian Government for an Australian Postgraduate Award. PT was the recipient of the University of Melbourne's McKenzie fellowship and the Seed Funding from the Melbourne Materials Institute and The Bio21 Institute of Molecular Science and Biotechnology (Bio21) and now is a Vice Chancellor's Research Fellow at Queensland University of Technology.