Journal article

Accuracy of Dose Calibrators for Ga-68 PET Imaging: Unexpected Findings in a Multicenter Clinical Pretrial Assessment

Dale L Bailey, Michael S Hofman, Nicholas J Forwood, Graeme J O'Keefe, Andrew M Scott, Winifred M van Wyngaardt, Bonnie Howe, Olga Kovacev, Roslyn J Francis

JOURNAL OF NUCLEAR MEDICINE | SOC NUCLEAR MEDICINE INC | Published : 2018

Abstract

We report the discovery of a systematic miscalibration during the work-up process for site validation of a multicenter clinical PET imaging trial using 68Ga, which manifested as a consistent and reproducible underestimation in the quantitative accuracy (assessed by SUV) of a range of PET systems from different manufacturers at several different facilities around Australia. Methods: Sites were asked to follow a strict preparation protocol to create a radioactive phantom with 68Ga to be imaged using a standard clinical protocol before commencing imaging in the trial. All sites had routinely used 68Ga for clinical PET imaging for many years. The reconstructed image data were transferred to an i..

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Grants

Funding Acknowledgements

This clinical trial is funded by a grant from the Movember Foundation through the Prostate Cancer Foundation of Australia's Research Program and administered through the University of Melbourne. Michael Hofman is supported by a Clinical Fellowship Award from the Peter MacCallum Foundation. Andrew Scott is supported by an NHMRC Senior Practitioner Fellowship. No other potential conflict of interest relevant to this article was reported.