Journal article
The emerging role of Rab GTPases in the pathogenesis of Parkinson's disease
Y Gao, GR Wilson, SEM Stephenson, K Bozaoglu, MJ Farrer, PJ Lockhart
Movement Disorders | WILEY | Published : 2018
DOI: 10.1002/mds.27270
Abstract
The identification of pathogenic mutations in Ras analog in brain 39B (RAB39B) and Ras analog in brain 32 (RAB32) that cause Parkinson's disease (PD) has highlighted the emerging role of protein trafficking in disease pathogenesis. Ras analog in brain (Rab) Guanosine triphosphatase (GTPase) function as master regulators of membrane trafficking, including vesicle formation, movement along cytoskeletal networks, and membrane fusion. Recent studies have linked Rab GTPases with α-synuclein, Leucine-rich repeat kinase 2, and Vacuolar protein sorting 35, 3 key proteins in PD pathogenesis. In this review, we discuss the various RAB GTPases associated with PD, current progress in the research, and p..
View full abstractGrants
Awarded by Michael J. Fox Foundation for Parkinson's Research
Funding Acknowledgements
This work was funded in part by National Health and Medical Research Council Australia Project Grant APP1041860 and Michael J Fox Foundation Grant 12173 to P.J.L. In addition, funding was received from the Victorian State Government Operational Infrastructure Support and Australian National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme (IRIISS).